Objective: To determine the annual prevalence of patients with advanced Parkinson’s disease (APD) in patients diagnosed of Parkinson’s disease (PD) in the hospitals of the Spanish public health care system.

Background: In Spain, PD prevalence has been calculated in few regional studies of limited scope. Moreover, any of them have been calculated the proportion of APD [1-6].

Method: Epidemiologic, cross-sectional, multicenter, national study which primary endpoint was to calculate the proportion of patients with APD. APD diagnosis was based on the clinical judgment, using the diagnostic questionnaire for Advanced Parkinson’s Disease (CDEPA questionnaire). The interim analysis is presented with the first 500 patients included in the study. Final endpoint recruitment is 800-1100 patients. Centres (17) were selected using a stratified randomization by type of Neurology service: general neurology service, general neurology service with a PD monographic office and neurology service with a Movement Disorders Unit.

Results: Among the 500 patients evaluated, 185 were categorized as APD; prevalence was 37.00% (CI 95%: 32.7%-41.4%). Of these 185 patients, 52.97% were women, the mean age was 74.72±9.52 years and they presented a disease evolution of 10.79±6.01 years. 68.6% referred to have presented pre-motor symptoms at the time they were diagnosed. In baseline visit, out of the 173 patients that were assessed in “On”, 1.62% had a H&Y 1; 16.22% 2; 55.68% 3; 22.70% 4 and 3.78% 5, with a median of 3.00 [2.00, 4.00]. 40% had any concomitant disease at the time of the study.

Conclusion: In this interim analysis, 37.00% of the PD patients treated in Neurological Departments of the Spanish public health care system present an advanced Parkinson’s disease.

References: 1. Artázcoz Sanz MT, et al. The estimation of prevalence of Parkinson’s disease in Navarra. An epidemiological study of the consumption of antiparkinsonian drugs. Rev Esp Salud Publica 1995; 69: 479-85. 2. Benito-León J. et al. Prevalence of PD and other types of Parkinsonism in three elderly populations of central Spain. Mov Disord 2003; 18: 267-74. 3. Bergareche A, et al. Prevalence of Parkinson’s disease and other types of parkinsonism. A door-to-door survey in Bidasoa. Spain. J Neurol 2004; 251: 340-5. 4. Clavería LE, et al. Prevalence of Parkinson’s disease in Cantalejo. Spain: A door-to-door survey. Mov Disord 2002; 17: 242-9. 5. Martínez-Pérez JA, et al. Epidemiology of parkinsonism in the Guadalajara Health Area. Semergen 2014; 40: 305-12. 6. Errea JM, et al. Prevalence Of Parkinson’s disease in lower Aragon. Spain. Mov Disord 1999; 14: 596-604.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/prevalence-of-advanced-parkinsons-disease-in-patients-treated-in-the-hospitals-of-the-spanish-public-health-care-system-paradise-study-interim-analysis/