Objective: The therapeutic role of Deep Brain Stimulation (DBS) has expanded for severe primary and secondary dystonias. Till date, only a few centres in India are offering DBS for dystonia. We report our experience of DBS in dystonia at the National Institute of Mental Health & Neuro Sciences (NIMHANS), Bangalore, India.

Background: To Quantify our experience in management of Dystonias.

Methods: This is a chart review of 10 patients who underwent DBS for dystonia at NIMHANS.

Results: Over the past 6 years we have done bilateral globus palllidus interna (GPi) DBS for 10 patients (7 men, 3 women). with dystonia. The mean age of the cohort was 30.6±14.46 years. The youngest patient was 6 years and eldest 57 years. The duration of illness was 10.0±6.73 years. Diagnosis included two patients each with primary generalised dystonia and neurodegeneration with brain iron accumulation, one patient each with Wilson’s disease, Parkinson’s disease-dystonia complex, camptocormia, secondary hyperparathyroidism, post-encephalitic sequelae and dystonia-myoclonus-ataxia syndrome. All patients were given adequate trials with appropriate oral medications and botulinum toxin injections as indicated before considering DBS. Seven patients had >50% improvement on long term follow. The remaining three patients showed good improvement in early follow up. However, one of the latter (the youngest patient who had NBIA) developed lead infection, for which the DBS leads were removed.

Conclusions: The results of pallidal DBS in this small cohort of patients with primary as well as secondary generalized dystonia are encouraging. Long term follow up studies on larger cohort of patients are required to determine the exact role of GPi DBS in primary and secondary dystonias.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/experience-of-pallidal-deep-brain-stimulation-dbs-in-dystonia-at-a-tertiary-care-centre-in-india/