Objective: To find out influence of botulinum toxin (BonT) treatment on improvement of motor symptoms and pain.To find out influence of botulinum toxin (BonT) treatment on improvement of motor symptoms and pain.

Background: Patients with cervical dystonia suffer from motor and non motor symptoms, including pain. Best treatment option is BonT applications.

Method: Forty one patients with idiopathic focal cervical dystonia treated in botulinum toxin ambulance were include. Data about age, sex, disease duration, treatment period, number of BonT applications, BonT doses and period between two applications were collected from patients record. For treatment response (motor symptoms and pain) we used patients subjective assessment about improvement measured in percentages and for severity of motor symptoms we used last measured modified Tsui scale.

Results: We have found positive correlation between improvement in pain scale with mean BonT dosage (P<0,002), total number of applications (P<0,03) and length of treatment (P<0,04). Patients with better improvement in pain score received more than 200 IU BonT (P<0,007), were treated more than 5 years (P<0,01) and received more than 10 BonT applications (P<0,02). We haven`t found any correlation neither difference between treatment duration, number of applications, BonT dosage, period between two applications and improvement in motor symptoms neither in long-term motor symptoms severity. There were no difference in between sex, age and disease duration in improvement or severity of motor symptoms and pain.

Conclusion: Higher BonT dosage, longer treatment period and higher total number of applications improve pain in patients with cervical dystonia. Improvement of motor symptoms depend more on good application technique and good muscle selection.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/effect-of-botulinum-toxin-treatment-on-cervical-dystonia/