Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: This study was designed to explore the clinical features of constipation, and investigate the risk factors of constipation in Chinese PD patients.
Background: Constipation is one of the earliest non-motor symptoms in PD, with a median prevalence of 40% to 50%,which may occur earlier than PD motor symptoms for 20 years. It’s also one of the important markers of prodromal PD. To study the clinical features of constipation in PD will make great significance for early diagnosis and treatment of PD.
Method: We collected data of outpatients and inpatients with PD of our hospital from February 01, 2017 to April 30, 2018. All patients in this study met the standard of clinically established PD or clinically probable PD in the 2015 MDS and 2016 Chinese clinical diagnostic criteria for Parkinson’s disease. 2440 patients were included in the PD constipation analysis. PD patients were collected general demographic data、present history, past history, personal history, environmental factors and LEDD, evaluated UPDRS, H-Y stage, WOQ-9, NFOG-Q, MMSE, NMSS, SCOPA-AUT, Rome Ⅲ functional constipation diagnostic criteria, RBDQ-HK, ESS, PDSS, HRS, HAMD and PDQ39. SPSS 20.0 software was used to analyze those clinical data.
Results: 1. PD patients with constipation had longer duration, higher LEDD, higher incidence of motor complications, more severe motor symptoms and NMS (p<0.05), those same as PD patients with constipation after motor symptoms. 2. Low BMI (p<0.001, OR=0.934), long disease duration (p=0.003, OR=1.037), old age (p<0.001, OR=1.040), high rigidity scores (p<0.001, OR=1.056), high H-Y stage (p<0.001, OR=1.337), voiding dysfunction (p<0.001, OR=1.048), high RBDQ-HK scores (p<0.001, OR=1.021), high HAMD score（p<0.001, OR=1.044）and low HRS scores (p<0.001, OR=1.044 ) were risk factors for constipation in PD patients, high tremor scores (p=0.010, OR=0.962) was a protective factor for PD constipation.
Conclusion: Long disease duration, older age, high rigidity scores, high H-Y stage, voiding dysfunction, hyposmia, RBD, and depression were risk factors for constipation in PD.
To cite this abstract in AMA style:
LP. Zhu, XT. Zhou, Z. Zhou, LJ. Fang, XX. Zhou, YW. Zhao, LX. Qin, Y. Tian, ZQ. Wang, QY. Sun, Q. Xu, JC. Li, JF. Guo, XX. Yan, BS. Tang. Clinical features of constipation in patients with Parkinson’s disease: a cross-sectional study in China [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/clinical-features-of-constipation-in-patients-with-parkinsons-disease-a-cross-sectional-study-in-china/. Accessed November 22, 2024.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/clinical-features-of-constipation-in-patients-with-parkinsons-disease-a-cross-sectional-study-in-china/