Objective: To study the clinical features and correlative factors of AutD in Chinese PD.

Background: Autonomic dysfunction (AutD), which is defined as dysfunction of the autonomic nervous system, is one of the most common non-motor symptoms (NMS) in Parkinson’s disease (PD). AutD has been regarded to be a crucial factor that affects mobility and disease progression in PD.

Method: A large cohort of 2047 PD patients consecutively recruited between February 1, 2017 and November 11, 2018 were enrolled. The assessment of AutD was performed by scale for outcomes in PD for autonomic symptoms (SCOPA-AUT). Motor symptoms (MS) and NMS were evaluated by a series of scales.

Results: 1.We found that urinary system dysfunction with prevalence of 74.01%, was the most common symptom of AutD in Chinese PD patients, followed by gastrointestinal dysfunction (71.32%), thermoregulatory disorders (43.97%), cardiovascular system dysfunction (22.42%), sexual dysfunction (17.91%) and pupillomotor dysregulation (17.90%). 2. Compared to PD without AutD, patients with AutD had older age, higher proportion of male, older onset age, longer disease duration, higher H&Y stage, severer motor complications and more other NMS (p<0.05). 3. Age (OR=1.054, 95% CI: 1.027-1.083), disease duration (OR=1.096, 95% CI: 1.014-1.185), Non-Motor Symptoms Scale (NMSS) score (OR=1.053, 95% CI: 1.035-1.072) and Rapid Eye Movement Sleep Behavior Disorder (OR=3.794, 95% CI: 1.752-8.215) were related to AutD in Chinese PD.

Conclusion: The large-scale study is of great significance for providing a clinical overview and clues for etiology of AutD in Chinese PD patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/characteristics-and-correlative-factors-of-autonomic-dysfunction-in-chinese-parkinsons-disease/