Objective: We studied the dependence of the nature of pain on the clinical form of PD and examined the effect of drug treatment of PD on pain syndrome.

Background: Pain syndrome, one of the leading non-motor manifestations of Parkinson’s disease (PD), and may be associated with PD itself, or be the result of anti-Parkinsonian therapy.

Method: There were examined 35 patients with PD in the 1st Clinical Hospital of Tashkent Medical Academy. The main group consisted of 25 patients with PD with pain syndrome, the control group consisted of 10 patients with PD who does not have any pain symptoms. Pain syndrome was evaluated on the basis of the modern classification of pain syndrome.

Results: The study showed a direct dependence of the nature of the pain syndrome on the duration of PD (g = 0.65; p = 0.003). The longer patients suffered from Parkinson’s disease, the higher was the likelihood that they had a pain of a central nature. We found a direct dependence of the nature of the pain syndrome on the rate of disease progression (g = 0.4; p = 0.02). Periarthropathy and spondyloarthrosis were more characteristic for moderate PD progression. Central pain syndrome prevailed in the rapid pace forms of PD. The pain syndrome in PD at any of its stages was affected by anti-Parkinsonian therapy. Pain syndrome on VAS scale decreased by 3 points (50%) (p = 0.0015). Motor activity increased by 24 points (50%) (p = 0.032), daily activity by 20% (p = 0.02), depressive symptoms decreased by 5 points (37%) (p = 0.0031).

Conclusion: The nature of the pain syndrome depends on the rate of progression, the severity of the disease, the duration of the disease: in the initial stages of PD, myofascial pains are more common, as the disease progresses, they give way to central algorithms mainly on the side of greater motor deficit. Adequate anti-Parkinsonian therapy reduces the severity of pain.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/pain-assessment-and-pain-management-study-in-patients-with-parkinsons-disease-in-uzbekistan/