Objective: We aimed to establish, using MRI, the presence of differences in the thickness of the cortical layers in patients with early and developed stages of Parkinson’s disease (PD).

Background: Cortical layer dedicated study using MRI has not previously studied in Movement disorders in Uzbekistan before.

Method: There were examined 22 PD-patients with stages 2 (group 1) and 3 (group 2) according to the Khen-Yar functional scale, of which 12 patients had an akinetic-rigid form of the disease (54.5%), the remaining patients had mixed form of PD (45.5%). The examination protocol consisted of a clinical assessment with the determination of the stage of the disease, as well as the MRI scanning the patients.

Results: We found significant differences in the thickness of the cortex in both the left and right hemispheres of the brain. One of the most interesting obtained results is the degeneration in the area of the visual cortex. Pathology of the posterior dorsal cingulate gyrus (1 group –2,758; 2 –group – 2,624; p = 0.017) affects the performance of episodic memory operations and the ability to understand and be aware of the opinions of other people. There is a decrease in the thickness of the cortical layer (1 group-2.21; 2-group-2.11; p = 0.044), which negatively affects cognitive and mental disorders that develop in patients with PD. Changes in the fusiform gyrus (1 group-1.83; 2-group-1.75; p = 0.042) have a negative effect primarily on the state of cognitive functions of patients and is one of the mechanisms for the development of hallucinations.

Conclusion: The obtained data allow us to establish a connection between the non-motor manifestations of PD and the degeneration of certain cortical regions of the brain. In this regard, it is necessary to further develop and improve high-tech techniques that will contribute to clarifying the issues of pathogenesis and predicting the course of PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/mri-cortical-layer-study-in-patients-with-parkinsons-disease-in-uzbekistan/