Objective: Study the principle of cognitive impairment in Parkinson’s syndrome (brain cerebral circulation disorder, backdrop of atherosclerosis).

Background: Parkinsonism-neurologic syndrome is a disorderly degenerative disease of the nervous system, characterized by akinesia, rigidity, tremor in calmness and postural insufficiency. One of the pressing problems in the world of medicine. In the last 20 years, cerebral hemorrhages and atherosclerosis have been associated with Parkinson’s syndrome. Loss of cerebral blood vessels is one of the main causes of Parkinsonism development. The first symptoms of the disease appear in the 50’s and 60’s of the patient’s life.

Method: Neurology Department presented 24 patients with cognitive impairment in Parkinson’s syndrome. 46% of them (11) had cerebral (75% male, 25% female) atherosclerosis, 37% (9) hypertension (40% in men, 60% in women), 17% (4) (75% in men and 25% in women). Both patients have an average age of 58 and 10 for men and 14 males. Cognitive functions were evaluated in a total 30-point scale in the MMSE scale. The scale was inspected at 9 stages. 23 points (19-27) for women in the MMSE scale; in men with 25 points (18-28).

Results: Cognitive disorders are mainly: recall – 85% (20) (80% of men), (100% of women); attention  and calculation: 57% (14) (40% men), (100% women); repetition-100% (24)  (100% of men), (100% for women);complex commands-100% (24) (100% of men), (100% of women); orientation to time – 17% (4) (50% men, 50% women); orientation to place – 0%; registration – 0%; language- 0% in patients.

Conclusion: Patients with parkinsonism need to conduct a comprehensive neuropsychological study for the early detection of cognitive impairments and groups of risk with the inevitable progression of cognitive impairments and the further formation of dementia for the timely start of their correction.

References: 1.Association between mild parkinsonian signs and mild cognitive impairment in a community-ED Louis, N Schupf, J Manly…-Neurology,2005-AAN Enterprises 2.The distinct cognitive syndromes of Parkinson’s disease: 5 years follow-up of the CamPaIGN cohort-CH Williams-Gray,JR Evans,A Goris, T Foltynie-Brain,2009 3.Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson’s disease-AA Kehagia, RA Barker, TW Robbins -The Lancet Neurology-2010

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MDS Abstracts - https://www.mdsabstracts.org/abstract/cognitive-impairment-in-patients-with-parkinsons-syndrome/