Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: To investigate the influence of the peripheral immune profile in the development of cognitive impairment in PD.
Background: Dementia is frequent in advanced Parkinson’s disease (PD), while mild cognitive deficits may be present even in early to intermediate disease stages. Peripheral immunity plays a role in neurodegeneration but its influence on the development of cognitive decline in PD is still unknown
Method: Fifty PD patients (30 males; mean age at onset 68.9±8.3; mean disease duration 4.6±3.5.) were recruited. All patients underwent a cognitive evaluation with MMSE and Addenbrooke’s cognitive examination (ACE-R). Mean MMSE score was 26.7±2.0; mean ACE-R was 85.6±8.7. The complete peripheral immune phenotype (CD4+ lymphocytes sub-populations Th1 and Th2) was examined with flow cytometry and data were retrospectively taken from a previously created database.
Results: Patients were divided in 3 groups depending on the ACE-R score (group 1:≥90; group 2:89-80; group 3:<80). We found that age at onset was significantly higher in patients with higher compared to lower ACE-R scores. Conversely, disease duration was similar among the 3 groups. Total number (x106/L) of Th1 lymphocytes increased (group 1:96.8±79.2; group 2:101.9±52.2; group 3:107.9±59.1) and Th2 decreased (group 1:65±53.5; group 2:62.78±63; group 3:49.6±20.9) progressively from group 1 to group 3. Accordingly, expression of GATA3, normally involved in Th2 differentiation, by lymphocytes showed a postive correlation with cogntive decline (p=0.04).
Conclusion: Higher age at onset is the main risk factor for dementia in PD. Patients with a worse ACE-R score showed a predominantly pro-inflammatory peripheral immune phenotype. Immune system may indeed represent a contributing factor in the development of dementia in PD.
To cite this abstract in AMA style:
L. Magistrelli, E. Storelli, V. Milner, E. Rasini, F. Marino, M. Cosentino, C. Comi. Influence of peripheral immune system on cognitive profile in Parkinson’s disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/influence-of-peripheral-immune-system-on-cognitive-profile-in-parkinsons-disease/. Accessed September 7, 2024.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/influence-of-peripheral-immune-system-on-cognitive-profile-in-parkinsons-disease/