Objective: To clarify the relationship between vascular risk factors and parkinsonism in Alzheimer’s disease

Background: This case-control study investigated the associations of a history of hypertension, dyslipidemia, and diabetes mellitus with the risk of parkinsonism in Alzheimer’s disease with dementia in Taiwan.

Method: A total of 1,243 Alzheimer’s disease patients were included in the study. Included were 250 cases, onset within 20 years of parkinsonism. Controls were 993 inpatients and outpatients with Alzheimer’s disease. All Alzheimer’s disease cases were diagnosed according to revised NIA-AA criteria. Data on the vascular risk factors and confounders were obtained from a self-administered questionnaire. The vascular risk factors were defined based on drug treatment and International Classification of Diseases (ICD) code.

Results: The proportions of hypertension, dyslipidemia, and diabetes mellitus prior to the onset of parkinsonism were 21.2%, 43.6%, and 24.8%, respectively. Hypertension, dyslipidemia, and diabetes mellitus were significantly associated with an increased risk of parkinsonism: the adjusted ORs were 2.335 (95% CI: 1.75–3.115), 2.054 (95% CI: 1.433–2.945), and 1.913 (95% CI: 1.367–2.678), respectively.

Conclusion: We found evidence of significant associations of hypertension, dyslipidemia, and diabetes mellitus with the risk of parkinsonism in Alzheimer’s disease in Taiwan. Further well-designed investigations of the association of vascular risk factors with the risk of parkinsonism in Alzheimer’s disease are needed.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/case-control-study-of-risk-developing-parkinsonism-in-alzheimers-disease-in-relation-to-hypertension-dyslipidemia-and-diabetes-in-taiwan/