Objective: Epidemiological studies of Indian population reveal that dementia is largely a hidden problem in India. Ayurveda claims several plants are beneficial in cognitive disorders. Pharmacoepidemiological studies reveal that herbal and allopathic learning and memory enhancing medicines are becoming very popular among Indian population. The objective of study was to we evaluated the effect Combined Alcoholic Extract of Cedrus deodara (Wood) Loud. and Vitex Nirgundi (Leaf) in scopolamine-induced cognitive impairment in mice.

Background: Current research effort focuses on the development of safer natural compounds with multipronged mechanisms of action that could be used to ameliorate memory deficits in patients In this study, we evaluated the effect Combined Alcoholic Extract of Cedrus deodara (Wood) Loud. and Vitex Nirgundi (Leaf) an Indian medicinal plant with significant neuro-pharmacological property on scopolamine-induced cognitive impairment in mice.

Method: Memory impairment was produced by administration of scopolamine (1mg/kg i. p) in rats. The alcoholic extract of Cedrus deodara (Wood) Loud. and Vitex nirgundi (Leaf) (30, 40 and 50 mg/kg, p.o.) was also administered to one group of animals. Passive avoidance paradigms, elevated plus maze and social learning task was used to assess learning and memory.

Results: Cedrus deodara (Wood) Loud. and Vitex nirgundi (Leaf) 50 mg/kg alcoholic extract treated group decreased transfer latency in elevated plus maze model paradigm which is an indicative of cognition improvement. In case of passive avoidance paradigm extract treated group exhibited prounced effect in reversal of scopolamine induced amnesia which was revealed by increase in step down latency. Social learning task also revealed the memory enhancing activity of combined extract.

Conclusion: The present findings indicate that the combined alcohalic extract of C. deodara and Vitex nirgundi has the best memory-enhancing effect due to its strong antioxidant properties from compounds like terpenoids and flavonoids. The study provides a scientific rationale for the traditional use of Cedrus deodara and Vitex nirgundi in the management of memory dysfunction and related disorders.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/memory-enhancing-effect-of-combined-alcoholic-extract-of-cedrus-deodara-loud-and-vitex-nirgundi-in-scopolamine-induced-cognitive-impairment-in-mice/