Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: The objective of conducting this study was to evaluate the expression of iNOS in mouse experimental model of PD.
Background: Parkinson’s Disease (PD) is one of the most common neurodegenerative diseases. Several molecular mechanisms are involved.
Method: PD was induced through injecting mice with 10 doses of MPTP (25 mg/kg) and probenecid (250 mg/kg). Mice in control group were injected by saline (25 mg/kg). Immunohistochemical stains for iNOS in brain sections were carried out using indirect immunoperoxidase techniques
Results: Study findings showed that there was a significant difference in the expression level iNOS in study groups (P<0.001) and experimental PD group had more expressed iNOS levels compared with control group. Taken together, the present study confirmed the impact of induction of iNOS in the etiology of PD
Conclusion: The present study confirmed the impact of induction of iNOS in the etiology of PD.
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To cite this abstract in AMA style:
N. Djebli. THE EXPRESSION OF INOS IN MOUSE EXPERIMENTAL MODEL POINTS TO INFLAMMATORY CONDITIONS ASSOCIATED WITH PARKINSON’S DISEASE [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/the-expression-of-inos-in-mouse-experimental-model-points-to-inflammatory-conditions-associated-with-parkinsons-disease/. Accessed September 7, 2024.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-expression-of-inos-in-mouse-experimental-model-points-to-inflammatory-conditions-associated-with-parkinsons-disease/