Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: The aim of this study was to study the role of perfusion single photon emission computed tomography (SPECT) in the examination of multiple system atrophy – parkinsonian type (MSA-P).
Background: Multiple system atrophy (MSA) is a disease lacking of efficient methods of diagnosis. Current criteria of diagnosis are based on conclusions from 2008 [1.]. Neuroimaging is mentioned among the additional features of possible MSA. Among factors presented in the context of neuroimaging, depending on the type of MSA (MSA-P or MSA-C) authors mention that magnetic resonance Imaging may reveal atrophy within the putamen, middle cerebellar peduncle, cerebellum or pons. Authors of the guidelines show also the use of positron emission tomography as an indicator of hypometabolism in the same regions. SPECT and PET are also mentioned in the context of imaging of dopaminergic denervation.
Method: 11 patients with clinical diagnosis of MSA-P aged 45 to 78 were assessed using SPECT HMPAO. The disease duration varied from 3 to 6 years. Perfusion was evaluated in various locations, and compared with data obtained from healthy volunteers, using Scenium software.
Results: Obtained results revealed the most significant hypoperfusion compared to control in the left thalamus, right gyrus rectus, left insula, left occipital lobe, left gyrus rectus, left hippocampus, left temporal lobe, left basal ganglia and left cerebellum. In those regions the average of standard deviations was between 0,85 and 2,00.
Conclusion: Results show that hypoperfusion can be observed in various regions, however hypoperfusion in the cerebellum in MSA-P and the overlapping of symptoms of MSA-P and MSA-C may question the boundaries between the diseases. Precise analysis requires more research in the field based on larger groups of patients.
References: 1. Gilman S et al, Second consensus statement on the diagnosis of multiple system atrophy, Neurology. 2008 Aug 26; 71(9): 670–676. doi: 10.1212/01.wnl.0000324625.00404.15
To cite this abstract in AMA style:
P. Alster, D. Koziorowski, L. Królicki, A. Friedman. Multiple System Atrophy – perspectives in diagnosis? [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/multiple-system-atrophy-perspectives-in-diagnosis/. Accessed November 22, 2024.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/multiple-system-atrophy-perspectives-in-diagnosis/