Objective: To see the demographic pattern of Parkinson’s Disease (PD) patients of India with onset of clinical symptoms prior to 50 years of age or those with family history of PD.

Background: Parkinson Research Alliance of India (PRAI) and Medgenome India are currently conducting a whole exome sequencing of Young onset Parkinson’s Disease patients in a multicenter Pan-India project.  This abstract is a partial presentation of demographic profile of this cohort.

Method: The subjects were recruited from nine different center from across India.  Inclusion criteria included, subjects with confirmed diagnosis of Parkinson disease along with age at onset being less than 50 years or subjects who had onset later than 50 years but with a strong family history of PD. The study was initiated in April 2017 and is currently still ongoing project. This abstract presents the clinical and demographic profile of these subjects.

Results: Over last 23 months, 699 subjects (M:F-473:222) have been recruited from across India (North India – 29.3%, South India – 38.2%, East India – 21.2%, West India – 10.3%, Bangaldesh – 0.7%).  These subjects were from various ethnic background (Hindus – 84.1%, Muslims – 12.5%, Christians – 1.4%, Sikhs – 1.3%, Jains – 0.4%) and educational status (9.6% had no formal schooling). The mean age of onset of motor symptoms was 39.2 yrs (Range-11 to 79 yrs) and duration of symptoms at recruitment was 97 months (Range: 1 – 432 months). Family history PD  was present in 20.8%. Among the affected patients 92.4% had asymmetric presentation (Left onset : 45%, Right onset- 49%). Subjects had varied frequencies of motor and non motor symptoms. The top non motor symptoms documented were – Fatigue – 53.2%, Pain – 47.2%, Constipation- 43.7%, depressive features – 44.5%, Anxiety – 44%, Sleep related issues – 32.1%, Bladder issues – 31.6%.  67.2% had noted dyskinesia at the time of recruitment and patterns of dyskinesia included : Peak dose dyskinesia – 87.7%, Biphasic – 11.8%, Off Dystonia – 10%. All PD subjects were on varied combination of therapies. About 7% of patients had undergone dopa scans, and most of the patients had some form imaging (CT/MRI brain).

Conclusion: This is the first major collaborative study from India showing the varied clinical features and demographic profile of young onset PD from the subcontinent.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/genetics-of-parkinsons-in-india-young-onset-parkinsons-disease-gopi-yopd-a-preliminary-demographic-profile/