Objective: To assess characteristics of advanced Parkinson’s disease (APD) patients with ongoing device-aided treatment stratified by caregiver support.

Background: Observe-PD is a multicountry, cross-sectional observational study conducted with 2615 PD patients at 128 movement disorder centers in 18 countries.

Method: The association between ongoing device-aided treatment (DAT) (i.e. treatment that extends beyond oral medications) and multiple clinical outcomes based on caregiver support was evaluated. The descriptive characteristics of the groups (ongoing DAT with caregiver support vs ongoing DAT without caregiver support) are presented.

Results: Overall, 2615 patients were included in this analysis. Of these patients, 181 patients (6.9%) planned to initiate DAT (63.5% having caregiver support), and 399 (15.3%) had ongoing DAT (with 71.2% having caregiver support). DAT patients with caregiver support had a higher age and slightly longer disease duration and duration of motor fluctuations. Motor, non-motor, and quality of life scores (mean±SD) for patients with ongoing DAT, with and without caregiver support, were 17.8±8.4 and 9.1±5.1 (UPDRS II- activities of daily living); 1.2±1.0 and 0.8±0.9 (UPDRS IV Q32- dyskinesia duration); 1.1±0.9 and 0.7±0.8 (UPDRS IV Q39- OFF time); 62.6±41.9 and 36.7±29.4 (NMSS total); and 40.8±18.5 and 23.1±15.3 (PDQ-8- quality of life), respectively [Table 1]. A regression analysis showed significant associations between ongoing DAT and caregiver support (P<0.0001).

Conclusion: APD patients with ongoing DAT having caregiver support showed higher scores for ADL and QoL, reflective of higher age and longer disease duration compared to patients without caregiver support.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/caregiver-support-and-its-association-with-advanced-parkinsons-disease-and-clinical-outcomes/