Objective: The aim of our study is to investigate the quality of sleep and the prevalence of excessive daytime sleepness(EDS) and nighttime problems in patients with Parkinson disease

Background: Sleep disorders are common nonmotor symptoms that affects quality of life patients with Parkinson’s disease(PD). Sleep disturbances and excessive daytime sleepiness in Parkinson’s disease are caused by multi-factorial etiologies, including dopaminergic medication, disease itself, concomittant depression, sleep-wake distruptions.

Method: A total of 140 patient who have been diagnosed with PD according to UK Parkinson’s Disease Society Brain Bank (UKPDS) criteria and 75 healty control have been included in the study. The clinical staging of PD was performed with Modified Hoehn&Yahr Staging Scale (HYS),  the measurement of clinical severity was performed with Unified Parkinson’s Disease Rating Scale (UPDRS), sleep quality was performed with Parkinson’s Disease Sleep Scale(PDSS), the Pittsburg Sleep Quality İndex(PSQI) and the Epword Sleepness Scale(ESS). Participants were also evaluated for their subjective levels of depression using the Beck’s Depression invertory.

Results: Hoehn and Yahr staging was 1,98±0,8 and UPDRS scales 35,1±17,9 in the 140 patients(%56,6 male, mean age 64,9±10,8 years and disease duration 6,38±5,31 years). The PSQI scale, ESS and Beck Depression Scale was significantly higher in patient group compared to control group. PD patient with poor sleep quality(PSQI>5) was %66,4 and EDS(ESS>10) was %17,1. According to evaluations of PDSS subgroups; the poor sleepers had lower scores for sleep quality, insomnia, nocturnal restless, nocturia and  sleep refreshment. EDS was possitively correlated with levodopa exposure time, Levodopa equivalent dosage, Beck Depression scores and was also negativly correlated nocturnal restless, nocturia, nocturnal psychosis, daytime dozing.

Conclusion: In our study, depression and EDS were higher and sleep quailty was lower rates in Parkinson’s patients compared to controls. In subgroup examination of PDSS, it was observed that decrease in sleep quality and EDS occured due to different etiological reasons. We believe that treatment for the reason of sleep disorder will increase treatment success and functionality in Parkinson’s patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/sleep-quality-in-turkish-patients-with-parkinsons-disease/