Objective: To study the genealogic features of Parkinson’s disease and essential tremor in people of Uzbek nationality.

Background: Parkinson’s disease (PD)  and essential tremor (ET) are one of the main hereditary neurodegenerative diseases of the brain, of which the clinical signs may be the same.

Method: 24 patients with PD, aged from 33 to 65 years (mean age 46.7±8.1 years), 12 men and 12 women and 26  patients with ET, aged from 24 to 55 years (mean age 46.7±8.1 years), 13 men and 13 women were examined.  The diagnosis was made by special criteria that can be differentiated. All patients were given genealogies on the basis of anamnestic examination.

Results: Based on long examinations, we found a familial case in 13 (54.1%) patients with PD and 18 (69.2%) patients with ET.  In 10 (41,6%)  patients with PD, an autosomal-dominant type was encountered, and in 14 (58.4%) patients an autosomal-recessive type. In patients with ET, an autosomal-dominant type was more common (84,6%). Of the 24 patients with PD, we found 11 patients who had all the signs of the disease embedded in the background of ET and observed rapid progressive course. In the remaining 13 patients, a slowly progressive course was observed. In all patients, ET was observed slowly in the qualitative course, which patients did not always complain.

Conclusion: In patients with PD and ET on the basis of conducting a genetic survey, it is not only possible to differentiate, but also for early diagnosis.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/hereditary-and-geneological-aspects-of-parkinsons-disease-and-essential-tremor-in-people-of-uzbek-nationality/