Objective: Evaluate the different neuropsychiatric manifestations in Parkinson’s disease.

Background: Parkinson’s disease (PD) is the second most common neurodegenerative pathology after Alzheimer’s disease, although PD is diagnosed clinically by its motor manifestations, it could be preceded and accompanied by neuropsychiatric troubles (NPT) such as: depression, anxiety, apathy, and hallucinations.

Method: Authors realized a prospectively study about 79 patients consulting for PD in the neurology department of the Mohammed VI University Hospital of Marrakech (Morocco) over a period of four months (between March 2018 and June 2018). Information was collected using the Neuropsychiatric Inventory (NPI) and by using a questionnaire, authors have described the different NPT during ON / OFF periods.

Results: Authors collected 79 cases including 43 men and 36 women. The average age of patients was 59 years old. The mean duration of disease was 7 years. The NPTs were more common in women and the NPI show a high score for depression, anxiety and mood instability. No correlation score items were found with age, however a significant correlation was established between apathy score (p <0.05, p = 0.02), hallucination score (p <0.05, p = 0.03) and duration of evolution of the MP. Depression, anxiety and panic attacks are the most frequent during OFF periods: 58 cases (73.42%), 55 cases (69.62%) and 46 cases (58.24%) respectively with an improvement found in 51 patients for depression, 46 patients for anxiety and 33 patients for panic attacks during ON periods.

Conclusion: NPTs have a significant impact on the quality of life of Parkinson’s patients and their families. Motor improvement by dopa therapy during unblocking periods ON seems to result in significant psychic improvement during PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/neuropsychiatric-manifestations-in-parkinsons-disease/