Objective: •To evaluate volume of Sub thalamic and Red nuclei on 3T MRI and its 3D reconstruction and its possible correlation with the disease progression in a patient with Parkinson’s disease.

Background: •The sub thalamic nucleus is themain target for Deep brain stimulation(DBS). •STN also has the portion of varied function and is either targeted indirectly or partial indirectly which is mainly dependent on red nucleus.•However, there is notmuch known about its volume and morphometry.•With high-resolution 3 Tesla (3 T) MRI may provide detailed information about microstructural changeswhich was limited with conventional MRI techniques previously.•Increasingly, 3 T voxel-based volumetric techniques that can detect subtle structural changes are being used in diagnosing PD and estimating disease severity.

Method: 11 patients with PD were enrolled. All patients, who are undergoing DBS surgeries, clinical data in the form of symptomatology, UPDRS, MOCA, MRI Brain were collected. The volumes of the SIN, RN and whole Brain were measured using 3-dimensional volume reconstructions of magnetic resonance images.

Results: The mean age of the patients was 52.18(42-60) years. The mean duration of symptoms was 8.27(4-19) years. There was no significant difference between right and left STN and red Nucleus volumes. The mean volume of sub thalamic nucleus was 195.59 (53-342) mm3 and red nucleus is 150.36 (96-196) mm3 and whole brain was 1428431(1281224- 1702240)mm3. STN volume is negatively correlated with Patient’s age (Pearson’s correlation coefficient is -0.56). STN volume is negatively correlated with Duration of disease (Pearson’s correlation coefficient is -0.78).

Conclusion: There is no significant difference between the right and left STN and RN volume. STN volume correlates negatively with disease duration.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/mri-based-volumetric-analysis-of-the-sub-thalamic-and-red-nuclei-in-advanced-parkinsons-disease-an-institutional-study/