Objective: To know the prevalence and characteristics of depression in PD patients of the COPPADIS-2015 cohort and its relationship with the other clinical aspects of PD.

Background: Depression is common in Parkinson’s disease (PD) and Beck Depression Inventory II (BDI-II) is a valid instrument for its evaluation.

Methods: Case-control study, using the baseline data of 694 PD patients and 206 controls of COPPADIS-2015 project. Depression was evaluated using BDI-II.

Results: Depression was more prevalent in PD patients than controls (49,8% vs 25,2%), p<0.001), the mean BDI-II score higher in patients group (13.01 ± 7.36 vs. 10.83 ± 6.26; p<0.05) and had higher score in all items except in “past failure”, “guilty feeling”, “suicidal thought or wishes” and “loss of interest of sex”. Depression subtypes distribution was: major (31.7% vs. 32%), minor (34.2% vs. 26%) and subclinical (34% vs. 42%). Female PD patients showed higher BDI-II scores than males (14.21 ±7.45 vs 11.93 ±7.17; p = 0.005), although gender differences disappeared when stratifying by depression types. The prevalence of depression, as well as the BDI-II scores increased significantly across H&Y stages I to IV (p<0.05). The prevalence of depression was higher in non-tremor dominant phenotype than in tremor dominant (54.98% vs 45.63%, p=0,05). Major depression was associated with higher Non Motor Symptoms Scale (NMSS), Neuropsychiatric Inventory (NPI) and PDQ-39 scores than minor depression, and the later than subclinical depression. UPDRS-III scores were higher (p<0.001) in major depression than in minor or subclinical ones. A high convergent validity (p<0.001) was observed among most BDI-II, NMSS, NPI and PDQ-39 items. A high correlation was also found between UPDRS-III and BDI-II and NMSS total scores. Regression analyses showed a strong influence of gender on patient’s BDI-II total score. In addition, gender plus age, and gender plus disease duration also influenced BDI-II total scores.

Conclusions: Depressive symptoms are frequently found in PD even in early stages, worsen with the disease duration and motor disability, and were more frequent among females with PD. Quality of life impairment, non-motor symptoms, and behavioral disturbances in PD subjects are highly correlated with the severity of depressive symptoms in PD.

References: Santos-García D, Mir P, Cubo E, Vela L, Rodríguez-Oroz MC, Martí MJ, Arbelo JM, Infante J, Kulisevsky J, Martínez-Martín P; COPPADIS Study Group. COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015), a global–clinical evaluations, serum biomarkers, genetic studies and neuroimaging–prospective, multicenter, non-interventional, long-term study on Parkinson’s disease progression. BMC Neurol. 2016 Feb 25;16:26. doi: 10.1186/s12883-016-0548-9.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/depression-bdi-ii-in-parkinsons-disease-prevalence-types-and-variables-associated-to-major-minor-and-subclinical-depression-in-coppadis-cohort/