Objective: Objective of present study was evaluate neuroprotective and antiparkinson effects of Mp seed extract on Parkinsons brain of rats.

Background: Parkinson’s disease (PD) is a multifactorial disorder, which is neuropathologically identified by age-dependent neurodegeneration of dopaminergic neurons in the substantia nigra. PD is a neurodegenerative disorder for which no neurorestorative therapeutic treatment is currently available. Recently studies, Mucuna pruriens (Mp) seed has been shown to possess antiparkinson and neuroprotective effects in animal models of Parkinson’s disease. Mp seed extract retard brain aging and help in regeneration of neural tissues besides producing anti-inflammatory and anti-oxidant and memory enhancing effect.

Methods: In present study 6-hydroxydopamine (6-OHDA) model of PD rat (n=8) were used. The symptoms of PD such as tremors, akinesia, rigidity, catalepsy, and vacuous chewing movements (VCMs) were evaluated. The methanolic extract of Mp seed was administered at doses of 200 mg and 500 mg/kg body weight followed by stress. The combination of L-dopa and carbidopa was used as a standard drug. Behavioral studies such as locomotor activity and grip strength were determined, and oxidative stress was evaluated in rat brain with biochemical and histopathological study. ANOVA was used followed by post hoc Turkey test.

Results: Animal exposed to stress showed significant decrease in superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total protein. This was accompanied by simultaneous increase in thiobarbituric acid reactive substances – TBARS level. Treatment with Mp seed had no significant but moderate effect on antioxidant enzyme (SOD and CAT). Pretreatment with Mp seed dose (200 and 500 mg/kg) significantly reduced the intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, and increase fighting behavior. The locomotor activity and grip strength were significantly increased by Mp seed extract treatment. Treatment with Mp seed extract significantly reduced LPO level and restored the defensive antioxidant enzymes SOD and CAT in rat brain.

Conclusions: Present study evidences that oral administration of alcoholic extract of Mp extract have shown antiparkinson , neuroprotective and anti-aging effects in animal models of Parkinson’s disease. Mp seed extract appreciably improve the neuroinflammatory processes and also restore biochemical and behavioral parameters.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/protective-effects-of-mucuna-pruriens-seed-on-rat-brain-a-therapeutic-potential-drug-for-parkinsons-disease/