Objective: We aimed to extend the evaluations of NMS in idiopathic RBD patients, Parkinson’s disease(PD) and multiple system atrophy(MSA) patients with RBD symptom occurring in advance (converted RBD).

Background: Patients with idiopathic rapid-eye-movement (REM) sleep behavior disorder (RBD) have a high risk for conversion to synuclein-mediated neurodegenerative disease. Previous studies have found that non-motor symptoms (NMS) can be present commonly in RBD patients, whereas there is little study on the comparison between NMS in idiopathic RBD patients and RBD patients with neurodegenerative conversion.

Methods: NMS were assessed in 83 idiopathic RBD patients, 79 controls as well as 79 converted RBD patients that include 52 PD patients and 27 MSA patients, through scales and examinations.

Results: NMS are common and severe in both idiopathic RBD and converted RBD patients. Cardiac autonomic dysfunction and EDS were associated with RBD symptom either in IRBD or converted RBD. Though hyposmia and constipation were severe in both IRBD and PD patients, hyposmia might be potential predictor of converted PD. Moreover, overall NMS burden, depression, complaint of memory decline remained at an intermediate level in IRBD patients and showed potential relevance to neurodegenerative diseases. Mild cognitive impairment was also observed in IRBD and MSA patients. Additionally, “Restless leg”, “Hallucination” and “hyposmia” were associated with PD, while severe cardiac autonomic disorder, decreased concentration and swallowing were indicated to have revalence to MSA.

Conclusions: Idiopathic RBD patients manifested variable abnormalities in certain NMS, which might be related with different neurodegenerative conversion. Furthermore, long-term follow-up of RBD patients will contribute to the explaination of the relationship between heterogeneous NMS and synucleinopathy.

References: 1. Schenck CH, Montplaisir JY, Frauscher B, et al. Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy–a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group. Sleep Med 2013;14:795-806. 2. Iranzo A, Tolosa E, Gelpi E, et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol 2013;12:443-453. 3. Postuma RB, Gagnon JF, Bertrand JA, Genier Marchand D, Montplaisir JY. Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials. Neurology 2015;84:1104-1113. 4. Aguirre-Mardones C, Iranzo A, Vilas D, et al. Prevalence and timeline of nonmotor symptoms in idiopathic rapid eye movement sleep behavior disorder. J Neurol 2015;262:1568-1578.

« Back to 2018 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/non-motor-symptoms-in-patients-with-idiopathic-and-converted-rem-sleep-behavior-disorder/