Session Information
Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Non-Motor Symptoms
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: The physiology of respiration is modulated by autonomic efferent neurons and circulating hormones. A continuous ambulatory monitoring of various respiratory parameters helps in early identification of sympatho-vagal(autonomic) dysregulation in Parkinson’s Disease(PD).
Background: We aim to compare different respiratory parameters in normal individuals and PD subjects & to detect autonomic dysregulation in PD subjects.
Methods: Prospective cross sectional study which included 40 subjects- 20 normal subjects and 20 diagnosed PD subjects (H& Y Stage <3) were conducted at the Departments of Neurosciences,Academic Medisch Centrum,Amsterdam,Netherlands & Sarada Hospital,Kochi,India.A 24hr ambulatory monitoring of each subject was done during the sleep-wake cycle &phases of activities using the respiratory inductance plethysmography.Respiratory parameters like Respiratory Rate Variability(RRV),Thoracoabdominal ratio(TAR%),& Low frequency-high frequency ratio(LF/HF) were assessed.
Results: Mean RRV during sleep in normal & PD subjects were 36.34% & 21.51% respectively.The study showed PD subjects showed lower respiratory rate variability than normal during sleep-wake cycle(p=0.01 & 0.02 respectively).Mean TAR% during sleep in normal and PD groups were 54.18% & 60.86% respectively. During awake state, PD subjects had significantly higher TAR% than normal(p=0.02).LF/HF ratios were highest in PD subjects compared to normal individuals throughout sleep-awake cycle & physical activities.(p=<0.001).
Conclusions: Our study showed the importance of using RRV,TAR%,LF/HF ratio as new surrogate markers for autonomic imbalance & sympath-vagal dysregulation and to detect early dysautonomia in PD subjects.
To cite this abstract in AMA style:
S. Menon R, A. Lutterotti. Autonomic Dysfunction in Parkinson’s Disease: Role of New Surrogate Markers [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/autonomic-dysfunction-in-parkinsons-disease-role-of-new-surrogate-markers/. Accessed September 7, 2024.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/autonomic-dysfunction-in-parkinsons-disease-role-of-new-surrogate-markers/