Session Information
Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: To examine the changes in connectivity of the attentional networks in Parkinson’s disease (PD) and their role in freezing of gait (FOG).
Background: Deficits in executive function, a cognitive domain that regulates attentional resources to multiple facets during an ongoing task, have been associated with FOG (1). However, the exact changes in the ventral and dorsal attentional networks that may contribute to FOG are unknown.
Methods: Resting-state fMRI was obtained in 20 healthy controls (HC) (age: 69.7±1.3ys; 50% male), 11 PD patients without FOG (PD-FOG) (age: 74.1±1.2yrs; 63.6% male; disease duration: 8.5±2.2), and 26 PD patients with FOG (PD+FOG) (age: 72.3±1.3yrs; 64% male; disease duration: 9.5±1.2). Seed to voxel analysis was performed at the whole brain level in the ventral and dorsal attentional networks and compared between the groups (2).
Results: Significant changes in connectivity were found in both attentional networks. Changes in the ventral network were observed only in the right nodes and included lower connectivity between the right insula and left anterior cingulate in all PD compared to HC (FDRcorr p<0.0036), and with left precuneus only in PD+FOG (FDRcorr p<0.014). Connectivity between the right inferior parietal lobe and superior temporal gyrus was higher in all PD, compared to HC, but more so in PD+FOG compared to HC (FDRcorr p<0.036). Connectivity between right BA10 with the superior temporal and frontal gyrus was higher in all PD (FDRcorr p<0.0075) and right BA10 had lower connectivity with left precentral gyrus (FDRcorr p<0.001) in all PD, but to a larger extent in PD+FOG. Changes in the dorsal network included higher connectivity between middle frontal gyrus and right putamen and superior temporal gyrus (FDRcorr p<0.042) in all PD compared to HC. However, PD+FOG showed lower connectivity than PD-FOG. Compared to HC, higher connectivity between left inferior parietal lobe and right precuneus was found only in PD+FOG (FDRcorr p=0.028).
Conclusions: Patients with PD have multiple alterations in the resting state functional connectivity of the ventral and dorsal attentional networks. A subset of these changes is more pronounced in PD+FOG, suggesting that altered connectivity in these networks may play a role in FOG.
References: (1) Vandenbossche J, Deroost N, Soetens E et al. Freezing of gait in Parkinson’s disease: disturbances in automaticity and control. Front Hum Neurosci 2012;6:356. (2) Tahmasian M, Eickhoff SB, Giehl K et al. Resting-state functional reorganization in Parkinson’s disease: An activation likelihood estimation meta-analysis. Cortex 2017;92:119-138.
To cite this abstract in AMA style:
I. Maidan, Y. Jacob, N. Giladi, J. Hausdorff, A. Mirelman. Altered connectivity in ventral and dorsal attentional networks in patients with Parkinson’s disease: Association with freezing of gait [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/altered-connectivity-in-ventral-and-dorsal-attentional-networks-in-patients-with-parkinsons-disease-association-with-freezing-of-gait/. Accessed September 7, 2024.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/altered-connectivity-in-ventral-and-dorsal-attentional-networks-in-patients-with-parkinsons-disease-association-with-freezing-of-gait/