Session Information
Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Cognition
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: To assess agreement between Parkinson’s disease (PD) patients (PT) and knowledgeable informants (KI) on the Penn Parkinson’s Daily Activities Questionnaire-15 (PDAQ-15). To explore conditions that lead to better agreement and to compare KI and PT scores to real-world performance.
Background: The PDAQ-15 is a questionnaire that assesses cognitive instrumental Activities of Daily Living (ADL) in PD. The PDAQ-15 is commonly administered to KIs of PD patients. Therefore it is of value to measure agreement between patients and KIs and to calculate who is closer to a performance based functional measure.
Methods: Global cognition (DRS-2), depression (GDS-15), caregiver burden, and the PDAQ-15 were administered to 274 PD patient and KI pairs. Discrepancy (D) between KI and PT was calculated as the total KI score minus the total PT score. A subset of the participants (n=65) were administered The Direct Assessment of Functional Status (DAFS) as a performance based functional measure. All patients were diagnosed as normal cognition (NC), mild cognitive impairment (MCI) or PD dementia (PDD) per an expert consensus panel based on MDS recommended criteria.
Results: PT and KI total scores were correlated (ICC= 0.820, p<0.005) but agreement was “fair” (K= 0.21-0.40). Factors that contributed to D were GDS-15 (t(250)= 4.579, p<0.001), DRS-2 (t(250)= 2.901, p<0.01), and caregiver burden (t(250)= -7.573, p<0.001). The mean D was significantly different between NC and PDD (mean difference= 6.098, p<0.001) and between MCI and PDD (5.459, p=0.004). Using previously published PDAQ-15 cut-off scores for NC, MCI and PDD, depression significantly increased disagreement between PT and KI (t(253)= -2.166, p<0.05). A partial correlation controlling for age, depression, and global cognition showed that the KI PDAQ-15 score was more strongly correlated with the DAFS (r=0.585, p<0.001) than the PT PDAQ-15 was (r=0.404, p=0.041) but both were significant.
Conclusions: Agreement between PT and KI on the PDAQ-15 was fair. Patient depression, impaired cognition and caregiver burden all increased disagreement between PT and KI. KI scores more closely resembled PT scores on a performance based functional measure. This supports the use of KIs as a proxy in assessing ADLs.
To cite this abstract in AMA style:
B. Deck, S. Xie, J. Rick, A. Chen-Plotkin, J. Duda, J. Morley, N. Dahodwala, J. Trojanowski, D. Weintraub. Agreement Between Patients and Informants on the Penn Parkinson’s Daily Activity Questionnaire [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/agreement-between-patients-and-informants-on-the-penn-parkinsons-daily-activity-questionnaire/. Accessed November 24, 2024.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/agreement-between-patients-and-informants-on-the-penn-parkinsons-daily-activity-questionnaire/