Objective: To explore the relationship between the female reproductive factors and cognitive decline/dementia with PD

Background: Cognitive dysfunction was the common non-motor features of Parkinson’s disease (PD), increasing with disease progress. Female reproductive experiences had potential effect on cognition in recent evident study. However, the relationship between the female reproductive factors and cognitive decline/dementia with PD was largely unknown.

Methods: Consecutive female PD patients with a large sample from the movement disorders outpatient department and inpatients department of West China Hospital between July 2014 and Aug 2017, were recruited into the present cross-sectional study. A variety of female reproductive factors were recorded. The cognition decline/dementia was assessed by Montreal Cognitive Assessment (Moca). Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were derived from ordinary logistic regression to identify the relationship between reproductive factors and cognition decline/dementia, as well as the predicting factors for cognitive impairments.

Results: 439 female PD patients were included for statistical analysis, consisting of 174(39.6%) PD-normal cognition (PD-NC), 174 (39.6%) PD-mild cognitive impairment (PD-MCI) and 91(20.7%) PD-dementia (PD-D) patients. Under adjustment of age, disease duration and education level, cognition decline/dementia was not significantly associated with female reproductive factors including age at menarche (OR=0.985, 95%CI 0.903 to 1.075), age at menopause (0.980, 0.935 to 1.027), fertile lifespan (0.988, 0.946 to 1.032), and whether menopause present before or after PD (1.522, 0.869 to 2.666), while multiparity (≥3) (2.070, 1.101 to 3.892) was associated with higher risk of cognition decline/dementia. Age (OR=1.061, 95%CI 1.030 to1.092), education level (4.341, 2.906-6.484) and the advanced stage of PD (Hoeh &Yahr staging≥3) (2.390, 1.394 to 4.099) independently predicted for cognition decline/dementia with female PD patients, but disease duration, depression, anxiety and age of onset fail to show association.

Conclusions: This study provides little support for an association between reproductive and cognition decline/dementia with female PD patients. Education level and advanced stage independently predicts cognition decline/dementia with PD in female patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/reproductive-factors-influence-on-cognitive-function-of-parkinsons-disease-in-female-patients-from-a-cross-sectional-study/