Objective: (1) Curcumin is well tolerated curcuminoid used as supplement for various disorders but problem is its low oral bioavailability. (2) Piperine is combined to enhance bioavailability of curcumin used as anti-inflammatory, neuromodulatory and neuroprotective in movement disorders like Parkinson’s disease.

Background: 6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine induced Parkinsonian rats was used to investigate the antioxidant, neuromodulatory and neuroprotective mechanisms.

Methods: Hemi-Parkinson’s rat model was developed with intranigral infusion of 6-OHDA (8 μg/2 μl, once, unilaterally), treatment with CMN (25 and 50 mg/kg) and combination of PP (2.5 mg/kg) with CMN (25 mg/kg) was given daily for 21 days starting from the 7th day after 6-OHDA infusion. The behavioral (locomotor, grip strength and narrow beam walk) parameters were performed on weekly basis. On 22nd day isolated brain preparations were subjected to biochemical (lipid peroxidation, glutathione and nitrite), neuroinflammatory (IL-1β, IL-6 and TNF- α) and neurochemical (DA, NE, 5- HT, GABA, Glutamate) analysis.

Results: Oral administration of CMN had significantly prevented behavioral, neuroinflammatory and neurochemical changes and preserved the antioxidant potential of the nigrostriatum in rats treated with 6-OHDA.

Conclusions: In the present study PP and CMN had afforded a better neuroprotective effect compared to alone treatment on behavior, biochemical, neuroinflammatory and neurochemical parameters in rats.

References: 1. Kumar, A., Sharma, N., Gupta, A., Kalonia, H. and Mishra, J., 2012. Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms. Brain research. 1471, 13-22. 2. Singh, S. and Kumar, P., 2016. Neuroprotective potential of curcumin in combination with piperine against 6-hydroxy dopamine induced motor deficit and neurochemical alterations in rats. Inflammopharmacology. 9, 1-11.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/neuroprotective-potential-of-curcumin-in-combination-with-piperine-against-6-hydroxy-dopamine-induced-motor-deficit-and-neurochemical-alterations-in-rats/