Objective: Purpose of investigation was to conduct a comparative assessment of cognitive impairment in Parkinson’s disease.

Background: According to modern concepts, parkinsonism – is not only a movement disorders. This symptoms also always accompanied by pathological changes by the higher brain functions, emotional sphere, other neurological systems.

Methods: Examined 31 patients with Parkinson’s disease (mean age 67,2±1,1 years) and 15 healthy persons (mean age 63,9±2,4 years). For assess of cognitive sphere used MMSEscale. In all patients with PD were conducted neuroimaging studies of the brain, which showed no changes indicative of vascular genesis of Parkinson’s syndrome.

Results: Examination of PD patients with MMSE cognitive disorders revealed in 87,1% of patients, 45,2% of them – mild cognitive impairment, 41,9% of them – dementia.Assistance correlation analysis had conducted to study the factors affecting the development of cognitive impairment in patients with Parkinson’s disease. It had shown that the severity of cognitive impairment irrespectiveage and gender of patients with PD. The dependence of the value of total score on the MMSE form PD: tremor-rigid (23,2±0,8), rigidly – tremor (26,7±0,5) and akinetic form (13,0±5,4). Found an inverse correlation between the duration of disease and the value of the total score on a scale MMSE. The higher level of education in patients with PD was associated with less severe cognitive impairment by MMSE.

Conclusions: The value of the total score from the MMSE, which characterizes cognitive function, depends on the duration, form of the disease, the level of education of patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/analysis-of-cognitive-disorders-of-parkinsons-disease-pd-in-the-comparative-aspect/