Objective: This study was conducted to determine the associations between the nutritional status and serum nutritional index and motor symptoms among patients with Parkinson’s disease(PD).

Background: PD patients tend to be more prone to nutritional problems. But in China, nutrition of PD patients is seldom considered in the clinical treatment and research. And so far, little is known about both the prevalence of malnutrition in Chinese PD patients and the association between malnutrition. To clarify these aspects, we conducted a study investigating malnutrition and associated factors in PD patients.

Methods: We enrolled in 72 patients with PD and 71 age-and-sex-matched healthy controls in this study and collected their Serum nutritional index, including serum albumin, prealbumin, transferrin, free fatty acid and retinol conjugated protein). The PD participants were interviewed and assessed using various motor and non-motor scales, including Hoehn and Yahr stage (H&Y), daily levodopa equivalent doses (LEDD), Body Mass Index (BMI), unified PD rating scale (UPDRS), Non-Motor Symptoms questionnaire for Parkinson’s disease (NMSS), Mini-mental State Examination (MMSE), the Unified Dyskinesia Rating Scale (UDysRS) and the 39-item Parkinson’s disease questionnaire (PDQ39).

Results: Serum albumin, transferrin, and free fatty acid of case group were significantly lower than those of control group (P <0.05 ~0.01). There was a significant negative correlation between serum albumin and UPDRS II(P=0.0031) and UPDRS IV(P=0.003). The forward binary Logistic regression model indicated that rigidity(OR =1.171, 95%CI: 1.013~1.354, P =0.032), akinesia(OR =1.07, 95%CI: 1~1.144, P =0.048), UDysRS (OR = 1.051, 95%CI: 1.004~1.099, P =0.032) and UPDRS IV(OR = 1.177, 95%CI:1.018 ~1.360, P =0.027) were closely associated with abnormal nutritional status. The differences of rigidity and akinesia in UPDRSIII, MMSE and UPDRS IV between normal nutritional status and abnormal nutritional status PD patients were statistically significant (P<0.05-0.01).

Conclusions: Serum nutritional index (serum albumin, transferrin, and free fatty acid) of case group were significantly lower than those of control group, PD patients tend to be more prone to nutritional deficiencies. In PD patients, the nutritional status and serum nutritional index are closely associated with motor symptoms. The disease duration and age of PD patients are related to the serum nutritional index, and the cognition and levodopa dosage is associated with the nutritional status.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/association-analysis-of-the-nutritional-status-and-serum-nutritional-index-in-patients-with-parkinsons-disease/