Objective: The aim of this study was to investigate the incidence of and risk factors for postoperative delirium (POD) after deep brain stimulation (DBS) surgery in patients with Parkinson’s disease (PD).

Background: The background of this study was to investigate the incidence of and risk factors for postoperative delirium (POD) after deep brain stimulation (DBS) surgery in patients with Parkinson’s disease (PD)

Methods: We analyzed the preoperative T1-weigthed magnetic resonance imaging data of 71 PD patients who underwent DBS surgery. Multiple regression analysis was done with age, l-dopa equivalent daily dose, laterality of the surgery, target regions, number of electrode trajectories tried, grey matter (GM) volume, and white matter (WM) volume as explanatory variables and the duration (number of days) of POD as the response variable. In addition, regional brain atrophy associated with POD was investigated by means of voxel-based morphometry.

Results: Excluding patients with outliers, 61 patients were included in the analyses. POD had occurred in 26 (42.6%) of the 61 patients. Age and total WM volume were shown by multiple regression analysis to correlate significantly with the duration of POD (p < 0.05 and < 0.01, respectively). WM was significantly reduced in the temporal stem, and the reduction in volume correlated significantly with the duration of POD (p < 0.001). GM atrophy was not associated with POD.

Conclusions: We found that age and WM atrophy in the temporal stem are factors predictive of POD after DBS surgery. In aged patients with temporal stem atrophy, surgical procedures and postoperative management should be carefully explored to reduce the risk of postoperative delirium.

« Back to 2018 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/after-deep-brain-stimulation-surgery-for-parkinsons-disease-risk-factors-for-postoperative-delirium/