Objective: To determine whether cognitive domain impairment of visuospatial, memory, attention is related to dysfunction of brain cholinergic neurotransmitter system in mild cognitive impairment of Parkinson’s disease.

Background: In recent years, more and more attention has been paid to the cognitive impairment of Parkinson’s disease. However, the pathogenesis of cognitive impairment of Parkinson’s disease remains unclear.

Methods: Seventy patients with Parkinson’s disease were collected. According to the Level-II level in the diagnostic criteria for mild cognitive impairment in Parkinson’s disease (PDMCI) as published by Movement Disorder Society,all non-dementia patients with Parkinson’s disease were divided into three groups:PD-CN group (35 cases) and PD-MCI group (35 cases). PD-MCI group was further divided into PD-MCI-EL group (PDMCI with executive function or/and language cognitive domain impairment group) (17 cases) and PD-MCI-NEL group (PD-MCI was not associated with executive function or/and language cognitive domain impairment group) (18 cases) according to the impairment of cognitive domain. Patients in the PD-MCI-EL group were not included in the study, because they all had impaired cognitive domains, such as memory, visuospatial, and attention, and no single cognitive domain (executive and/or language) impairment. All subjects underwent 3.0T GE MR whole brain imaging. Freesurfer software and two-sample t-test were used to compare the cortical thickness between PD-CN and PD-MCI and PD-MCI-NEL patients (P <0.01).

Results: PD-CN VS PD-MCI,PD-CN VS PD-MCI-NEL had no statistical significance in clinical data such as age, sex, course of disease, UPDRS-III, H-Y grade, HAMA and HAMD.Global cognitive function assessment showed that patients with PD-MCI had lower MMSE and MOCA scores than PD-CN. PD-CN VS PD-MCI (P <0.01): PD-MCI patients mainly in frontal lobe, temporal lobe, parietal lobe and parts of occipital lobe of the left and right hemisphere appears cortex thinning area. PD-CN VS PD-MCI-NEL(P <0.01): Patients in PD-MCI-NEL group had cerebral cortex thinning in inferiorparietal,parsopercularis,rostralmiddlefrontal,superiorparietal of the left hemisphere and in superiorfrontal, parahippocampal, superiortemporal, bankssts, inferiorparietal, caudalmiddlefrontal, parsopercularis, parstriangularis of the right hemisphere.

Conclusions: Cognitive domains impairments in memory, visuospatial and attention in patients who has mild cognitive impairment in Parkinson’s disease are closely related to cholinergic system dysfunction.

References: [1]. Kehagia AA, Barker RA, Robbins TW. Cognitive Impairment in Parkinson’s Disease: The Dual Syndrome Hypothesis. Neurodegenerative Diseases. 2013 11: 79-92. [2]. Gratwicke J, Jahanshahi M, Foltynie T. Parkinson’s disease dementia: a neural networks perspective. BRAIN. 2015 138: 1454-1476.

« Back to 2018 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/the-correlation-studies-between-cholinergic-cognitive-impairment-of-parkinsons-disease-and-the-cortex-thickness-of-brain/