Objective: Cross-sectional assessment of personality trait, impulsivity, depression and anxiety collected prospectively in Parkinson’s disease (PD) with impulse control disorders (PD-ICD) compared to a matched PD non-ICD “controls” (PD-C).

Background: ICD complicate treatment of PD with dopamine replacement therapy (DRT), particularly with dopamine agonists. Information on personality trait in ICD based on data collection from controlled studies is rare.

Methods: PD-ICD (N=34, 59% male, mean age 66.2±8.4yrs) and PD-C (N=30, 48% male, mean age 70.3±6.1) were assessed for demographic details (including duration of education), motor (Hoehn Yahr stage (HY)), depression (Geriatric depression rating scale), anxiety (State-trait anxiety inventory), impulsivity (Barratt impulsiveness scale-11 (BIS-11), the Russian validation) and the three-dimensional Eyesenck personality questionnaire (extroversion or introversion, neuroticism, lie scale (deliberate attempt to control their scores)).

Results: PD-ICD and PD-C were matched for age, duration of dopaminergic treatment (5.91± 4.2 vs 6.81 ±4.3 yrs), HY (2.2 ±0.1vs 2.4±0.1), levodopa equivalent dose (655.6±407 vs 713.4±297.7 mg) and mini-mental state. None were demented.  PD-ICD showed significantly worse depression (p=0.03), worse self-control (p=0,02, section 1, BIS-11) and highly significant worsening of neuroticism but no other personality trait.

Conclusions: Neuroticism (emotionality with negative affect) along with depression and poor self-control is associated with ICD. Management of ICD, therefore, needs neuropsychological support of patients.    

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MDS Abstracts - https://www.mdsabstracts.org/abstract/neuroticism-and-depression-is-associated-with-impulse-control-disorder-in-parkinsons-disease-a-controlled-study/