Session Information
Date: Tuesday, June 6, 2017
Session Title: Tremor
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: We aimed to reveal cerebellar dysfunction in patients with essential tremor using neurophysiological methods.
Background:
Cerebellar dysfunction is suggested to contribute to tremor generation. However, in essential tremor (ET), cerebellar functions have not been fully studied with physiological methods.
Methods:
Participants were 20 patients with ET and 30 age-matched healthy volunteers. We used two methods to study cerebellar function. One was Cerebellar inhibition (CBI): the motor cortical inhibition evoked by cerebellar stimulation. The other was prism adaptation: motor performance adaptation to visual angle perturbation induced by prism glasses. The results were compared across the groups.
Results:
CBI was reduced and prism adaptation were affected in patients with essential tremor.
Conclusions: Our results suggested that cerebellum should be involved in ET even though the patients had no clinical ataxic symptoms. The cerebellar dysfunction shown here may reflect a primary pathogenic abnormality or secondary compensatory physiological phenomenon to an original pathogenic lesion elsewhere
To cite this abstract in AMA style:
R. Hanajima, R. Tsutsumi, Y. Shirota, T. Shimizu, N. Tanaka, Y. Ugawa. Prism adaptation and cerebellar inhibition were impaired in essential tremor [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/prism-adaptation-and-cerebellar-inhibition-were-impaired-in-essential-tremor/. Accessed September 7, 2024.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/prism-adaptation-and-cerebellar-inhibition-were-impaired-in-essential-tremor/