Session Information
Date: Wednesday, June 22, 2016
Session Title: Parkinson's disease: Neuroimaging and neurophysiology
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To compare the power spectral densities of local field potentials recorded from the cortico-basal ganglia loop of a subacute (reserpine) and a chronic (6-OHDA) animal model of Parkinson´s disease.
Background: Pathologically enhanced beta-oscillations have been found in deep brain recordings from human DBS-patients and in chronic animal models of PD. Recent correlative evidence suggests that beta-oscillations may play a pivotal role in the generation of the disease symptoms akinesia and rigidity. It is not known so far, if beta oscillations can also be found in the subacute reserpine model of Parkinson´s disease.
Methods: Two animal models of PD, the reserpine and the 6-OHDA model, were compared with controls. In the 6-OHDA group we injected 8 μg of the neurotoxin unilaterally into the medial forebrain bundle of n=10 wistar rats. Recordings were made 20-30 days following the lesion. Reserpine (3mg/kg i. p.) was given 18 hours before the start of the experiment in n=9 rats. As healthy controls we used n=9 rats. We performed simultaneous recordings of LFPs from the primary motor cortex (M1), subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr) under urethane anaesthesia. We calculated power spectral densities and coherences using custom written Spike 2 scripts.
Results: Significantly enhanced beta synchronization could be detected in the power spectral densities of the STN and the SNr of both animal models compared to healthy controls. However, the peak frequency differed substantially between the two groups (6-OHDA: STN-17Hz, SNR-15Hz; reserpine: STN-27Hz, SNR-28Hz). In the 6-OHDA group a beta peak was also found in M1 at 18Hz, which was not detected in the cortex of rats treated with reserpine. Beta coherences between the M1 and the STN/Snr were also elevated in both models, again with peaks at 18Hz for the 6-OHDA group and 28Hz for the reserpine group.
Conclusions: Our data show that enhanced beta-oscillations are a prominent feature of the pathophysiology in the cortico-basal ganglia of the reserpine and the 6-OHDA model of PD. The role of the different beta peak frequencies has to be further investigated.
To cite this abstract in AMA style:
C. van Riesen, J.K. Haumesser, J. Kühn, A. Kühn, M.H. Beck. Pronounced beta oscillations are a characteristic of the cortico-basal ganglia loop of subacute and chronic animal models of Parkinson´s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/pronounced-beta-oscillations-are-a-characteristic-of-the-cortico-basal-ganglia-loop-of-subacute-and-chronic-animal-models-of-parkinsons-disease/. Accessed November 22, 2024.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/pronounced-beta-oscillations-are-a-characteristic-of-the-cortico-basal-ganglia-loop-of-subacute-and-chronic-animal-models-of-parkinsons-disease/