Session Information
Date: Tuesday, June 6, 2017
Session Title: Parkinson's Disease: Pathophysiology
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: In this study, we explored the neuronal firing activity of excitatory pyramidal cells and inhibitory interneurons in the forelimb region of the primary somatosensory cortex (S1FL-Ctx), along with its interaction with oscillatory activity of the primary motor cortex (MCtx) in 6-hydroxydopamine lesioned hemiparkinsonian (HP) and levodopa-primed dyskinetic (HP-LID) rats as compared to controls.
Background: Several findings support the concept that sensorimotor integration is disturbed in Parkinson`s disease (PD) and in levodopa-induced dyskinesias.
Methods: Rats were rendered hemiparkinsonian (HP) by unilateral injection of 6-OHDA in the medial forebrain bundle (MFB). Subsequently, these HP rats were divided into one group that was rendered dyskinetic by long-term injections of levodopa, in the following termed HP-LID rats, while the other HP group received no levodopa injection. Another group of rats without surgery served as naïve controls. The firing activity of excitatory pyramidal cells and inhibitory interneurons in the S1FL-Ctx, along with its interaction with oscillatory activity of the MCtx was recorded in urethane anesthetized (1.4 g/kg, i.p.) rats.
Results: While firing frequency and burst activity of S1FL-Ctx inhibitory interneurons were reduced in HP and HP-LID rats, measures of irregularity were enhanced in pyramidal cells. Further, enhanced coherence of distinct frequency bands of the theta/alpha, high-beta, and gamma frequency, together with enhanced synchronization of pyramidal cells and interneurons with MCtx oscillatory activity were observed.
Conclusions: Our study shows electrophysiological alterations in the sensorimotor cortices in a rat model of PD, which differ depending on the functional state after dopamine depletion and treatment indicating maladaptive neuroplasticity.
To cite this abstract in AMA style:
K. Schwabe, X. Jin, J. Krauss, M. Alam. Altered somtatosensory cortex neuronal activity in a rat model of Parkinson`s disease and levodopa-induced dyskinesias [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/altered-somtatosensory-cortex-neuronal-activity-in-a-rat-model-of-parkinsons-disease-and-levodopa-induced-dyskinesias/. Accessed November 22, 2024.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/altered-somtatosensory-cortex-neuronal-activity-in-a-rat-model-of-parkinsons-disease-and-levodopa-induced-dyskinesias/