Objective: To assess lower urinary tract symptoms (LUTS) in patients with Parkinson’s disease (PD) and to investigate their impact on the quality of Life (QoL).

Background: Prevalence of LUTS in PD varies widely (27-71%) according to studies’ methodology.  The assessment of their impact on QoL with validated questionnaires has been performed seldom.

Methods: We prospectively assessed 32 patients with PD (16 men and 16 women), at the Neurology department of Razi Hospital. Hoehn–Yahr scale (HYS) and Unified Parkinson Disease Rating scale (UPDRS) were used to assess motor status. Autonomic symptoms were evaluated by SCOPA-AUT. LUTS and their impact on QoL were assessed by International Prostate Symptom Score (IPSS). QoL was assessed with Qualiveen short form score (SF-Qualiveen).

Results: Mean age and duration of the disease were respectively 64.34 and 13.3 years. At least one LUTS was reported by 29 patients (90%). Mean IPSS was 4,22. Nocturia was the most prevalent symptom, affecting 90% of patients, followed by urgency (84%), incontinence (75%) and pollakiuria (69%). There was no significant difference in urinary symptoms according to gender. In men, 15/16 had erectile dysfunction. Mean motor UPDRS was 37,6. Most patients had HYS>3 in 72%. Mean SCOPA-AUT score was 16 with no significant difference according to sex. Mean SF-Qualiveen score was 1,23. Only incontinence was significantly associated with worse SF-Qualiveen score (p=0,035).

Conclusions: Our study showed the high frequency and severity of urinary symptoms in patients with PD, independently from gender. Incontinence seems to be the main type of LUTS affecting QoL, and it is probably due autonomic dysfunction especially in advanced stages of PD. Further investigations are needed earlier in the disease course.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/lower-urinary-tract-symptoms-in-patients-with-parkinsons-disease-findings-from-a-tunisian-cohort/