Objective:

Using a comprehensive analysis of clinical, medical history and social – hygienic data will examine the factors that determine the development of Parkinson’s disease.

Background:

The value of risk factors for  Parkinson’s disease has a lot of importance in the manifestation in the conditions of the southern regions of Uzbekistan, as in these regions is a number of chemical companies which directly affects to the condition of the body workers and the population living near these plants.

Methods: The study included 70 PD patients aged 30 – 85 years (mean – 55.8 + – 10.1 years). Of these, 38 patients were born and live in rural areas of Kitab district, 32 – in the city of Karshi, Kashkadarya region of Uzbekistan. The average age of the patients was: rural population – 53.08 + – 9.14 years, urban – 58.5 + – 10.7. The diagnosis was made based on the criteria of the brain bank UK Parkinson’s Disease Society (Hughes et al AJ af., 1992).

Results:

There is a tendency to an earlier onset of the disease in rural areas compared with urban residents (+ 48.8 respectively – 9.9 and 53.6 + -9.9 years). Also among the villagers there was noted predominance of men (61.1% of women – 38.9%), whereas among the urban population, on the contrary, a large number of patients were female (61.7%) than men (38.3%) , These trends are explained in agriculture men than women most exposed to the harmful effects of pesticides (butifos, magnesium chlorate, DDT – 30), insecticides (BI – 58, trichlorfon) herbicides. When analyzing the data of the average age debut PSU depending on the profession there was a trend to an earlier onset of the disease in the chemical industry workers (47.8 + – 8.4), agricultural workers (50.2 + -7.8) and teachers (51, 1 + -9.8). The early development of the disease in the teaching staff, compared with the group as a whole (+ 51.1 respectively -9.8 and 52.4 + -8.8) suggests a possible role in the manifestation of disease stress.

Conclusions:

This study showed that Parkinson’s disease is more common and more severe in patients living in rural areas compared with urban residents. Established an earlier age of onset of the disease among residents of rural areas (48.8 + -9.9 years) compared with those of the urban population (53.6 + -9.9). Patients living in rural areas, established adverse effects of pesticides (butifos, magnesium chlorate, DDT – 30), insecticides (BI – 58, trichlorfon).

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-value-of-various-risk-factors-in-the-manifestation-of-parkinsons-disease-in-the-southern-part-of-uzbekistan/