Parkinson’s Progression Markers Initiative (PPMI): Investigating Biomarker Driven PD Progression
Objective: PPMI is a longitudinal, observational study enrolling PD participants, individuals at risk for PD, and healthy controls (HCs). The study investigates clinical, imaging, genetic…Use of Machine Learning for Identification of Parkinson’s Disease and Mild Cognitive Impairment through Neuroimaging and Biofluid Biomarkers: A Study from the PPMI Cohort
Objective: Since current diagnostic tests for Parkinson’s Disease (PD) and mild cognitive impairment (MCI) focus on individual biomarkers, misdiagnoses can be frequent. This research aims…Characterizing Dopaminergic Correlates of Depression in Parkinson’s Disease: The PPMI Cohort
Objective: We explored the association between cerebrospinal fluid (CSF) dopamine metabolites and transporter denervation in the development of depression in Parkinson Disease (PD). Background: Depression…Characterization of a Novel alpha-synuclein PET radiotracer, [18F]C05-05, in a PPMI Sub-study
Objective: Characterization of the PET radiotracer, [18F]C05-05, in the PPMI Study Background: Validation of imaging biomarkers in Parkinson disease (PD) is a major objective of…Assessing the Accuracy of Clinical features, CSF Dopamine Metabolites, and Striatal Binding Ratios for the Likelihood of Depression Over 10-year Follow Up in the PPMI Cohort.
Objective: To identify whether MDS-UPDRS scores, Dopamine Transporter (DaT) Striatal Binding Ratios (SBRs), or dopamine metabolites cerebrospinal fluid (CSF) concentrations could predict the likelihood of…Creating myPPMI: an Online Portal to Deliver Study Participant Content
Objective: Building a centralized platform to collect patient reported outcomes and provide educational and informational content to participants Background: Patient portals are a valued healthcare…Baseline NSD-ISS stage predicts long term progression and survival in sporadic PD: 10-year PPMI data analysis
Objective: To analyze long term progression in Neuronal Synuclein Disease (NSD) participants who were originally enrolled in the sporadic Parkinson Disease (sPD) cohort in PPMI…Concordance of Neuropathologic Diagnosis of Lewy Body Disease with Baseline Alpha-Synuclein Seed Amplification Assay in PPMI
Objective: To determine whether the alpha-synuclein seed amplification assay (aSyn-SAA) performed on cerebral spinal fluid (CSF) collected at the baseline (BL) PPMI visit is concordant…Predictive Accuracy of Baseline DaT-SPECT for Freezing of Gait at 5, 7, and 10-year Follow up in The PPMI Cohort
Objective: To see if segmentation models of baseline DaT-SPECT striatal binding ratios (SBR) will predict freezing of gait (FoG) in Parkinson’s Disease over a 5,…The Contribution of APOE4 Genotype on Structural MRI in Parkinson’s Disease: A Study from the PPMI Cohort
Objective: To assess the contribution of Apolipoprotein E4 (APOE4) in Parkinson’s Disease (PD)-related cognitive impairment by analyzing its impact on Gray Matter Volume (GMV). Background:…
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Title
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Meeting
2024 International Congress -
Keyword
PPMI